MIJWP

Prompt

1.1.1.189

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. prostaglandin-E2 9-reductase.

AI Generated Sequence

397 AAs

MATKRVVLKLARGPNGLPVADNFRLEKAELPDEIKNGQVLLRTLYLSVDPYMRCRMNEDGTDYITPWELGEAIEGGGIGVVEESKHPGFAKGDLVTSFFWPWQTKAILDGNGLEKVDLQVLDGDVLSYFLGALGMPGLTSLAGILEIHGAKAKAGQTMVVSGAAGAVGSLAGQIGKLEGCSRVVGIAGTDEKCALLTKELGFDAAINYKVGNVAEQLREACPDGIDVYFDNVGGDISDAVISQMNKFGHIILCGQISQYNKDTPYPPPLPPEIAKQERITREGFIVLHMGDRFEPAILQLLQWVSEGKLKIKETVVAGLENIPGAFQSMMTGGNIGKQIIKVSDEKLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	91.1
NLMSIM	80.0
AACOMP	88.4
Seqdif (SeqID)	26.9 (XP_029807322.1)
Structdif (F-Target)	4.0 (2w98 A)

ProtNLM

Name	Score
15-oxoprostaglandin 13-reductase	0.323
1.3.1.48	0.195
Prostaglandin reductase 2	0.183
1.3.1.74	0.171
NAD(P)H-dependent alkenal/one oxidoreductase	0.027
Dithiolethione-inducible gene 1 protein	0.017