MIDGC

Prompt

1.1.1.88

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. hydroxymethylglutaryl-CoA reductase.

AI Generated Sequence

477 AAs
MTDSRIPGFRYLSVAERLAALAERAGLTDEERALLAGPGALPLAVADGMIENVIGTFELPLGVATNFQVNGRDVLVPMAVEEPSVVAAASYMARLARDCGGFTASSTEPLMRAQVQVVGVADPHGARLAILAAKDEILALANARDPVLVKLGGGCRDLEVHVFPTPRGPMLVVHLLVDVRDAMGANTVNTMAEAVAPLVERITGGRVRLRILSNLADLRLARARVRIPTEVLATGEYSGEEVVDGILDAYAFAAADPYRAATHNKGIMNGIDPVVVATGNDWRAVEAGAHAYAARDGRYTSLTTWEKDADGNLVGTIEMPMAVGLVGGATKTHPHARLALKILGVQSAQELAEVAVAVGLAQNMAALRALATEGIQRGHMALHARNIALAAGATGEEIDVVAARMVAEKDIRTDRARELLAARRAGEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT91.0
NLMSIM70.0
AACOMP81.5
Seqdif (SeqID)20.2 (CAB5515536.1)
Structdif (F-Target)6.1 (4i4b A)

ProtNLM

NameScore
HMG-CoA reductase0.396
1.1.1.880.293
3-hydroxy-3-methylglutaryl coenzyme A reductase0.276
Hydroxymethylglutaryl-CoA reductase, degradative0.020
1.1.1.340.005
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase0.001
Designed by MP, using an AMD MI250 GPU