MI3HS

Prompt

3.5.2.3

Hydrolases. Acting on carbon-nitrogen bonds, other than peptide bonds. In cyclic amides. dihydroorotase.

AI Generated Sequence

486 AAs
MKLLIKNGRIYDPATGLDGKVDILIEDGKIAAIGENIEAGEAEVIDAKGKLVLPGLVDLHVHLREPGFEYKETIETGSLAAAKGGFTTVAAMPNTKPVPDTKETMEYLLKRIRDTALVNVLPYGAITVGQKGKELTDMEALKEAGAFAFTDDGHGVQTAGMMYEAMQQAAALDMAIVAHCEDNSLTYGGCVHEGEVSTTLGLKGIPSICESVQVARDLLLAEAAGCHYHVAHVSTKASVRVIRDAKRAGIRVTAEVCPHHLILCDEDIPGMDTNYKVNPPLRGKADRDALIEGLLDGTIDCIATDHAPHAAAEKAQGMEAAPFGIVGLETAFPLLYTKFVKTGVFSLKQLVAKMSVAPAACFGLDKGRLAVGAPADITVLDLAAETEIDPATFLSKGRNTPFAGWTVYGWPKMTIVGGKLVFARGEVAGEAGAAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

Orotic acid

C1=C(NC(=O)NC1=O)C(=O)O

Validation Metrics

PLDDT95.0
NLMSIM90.0
AACOMP85.1
Seqdif (SeqID)27.7 (WP_119877524.1)
Structdif (F-Target)1.5 (4yiw A)

ProtNLM

NameScore
3.5.2.30.392
Dihydroorotase0.327
DHOase0.272
Amidohydro-rel domain-containing protein0.001
Amidohydrolase family protein0.000
Multifunctional fusion protein0.000
Designed by MP, using an AMD MI250 GPU