MI2KF

Prompt

1.5.1.6

Oxidoreductases. Acting on the CH-NH group of donors. With NAD(+) or NADP(+) as acceptor. formyltetrahydrofolate dehydrogenase.

AI Generated Sequence

898 AAs
MKIAVIGQSLFGQEVYSHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKFPRWRAKGQPIPEVVEAYKALGAELNVLPFCSQFIPMQVIDAPKHGSIIYHPSILPRHRGASAINWTLIMGDKKGGFSVFWADDGLDTGDILLQRECEVLPDDTVDTLYNRFLFPEGIKAMVEAVQLIADGKAPRIPQPEEGATYEGIQKKENAKIDWSQPAEAIHNWIRGNDKVPGAWTEVDGQTVTFFGSTLNSSVPASGQPLEIPGASRPGVVTKNGLVLFGNDGKMLLVKNVQFEDGKMIPASKYFAGSATSVELTEEEKKLAEAVRAIWRSILSNVGVIDDSTDFFKSGAASMDVVRLVEEVKKLCAGLELQNEDVYMATTFEDFIQMIVRKLRGEDEEECLIDYVNKSVANMKTVKMPHQCFINGEFVDAENGKTYDTINPTDGSVICQVSLAQVSDVDKAVAAAKEAFENGEWGRMNARDRGRLLYKLADLMEQHEEELATIESIDSGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTRKEPIGVCAVIIPWNYPLMMLSWKQAACLAAGNTVVLKPAQVTPLTALKFAELSLKAGIPKGVINILPGSGSLVGQRLSDHPDVRKIGFTGSTEIGKQIMKSCAVSNVKKVSLELGGKSPLIIFDDCDLDKAVRMGMSAVFFNKGENCIAAGRLFVEESIHDEFVKRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLMEYCQEGVKEGATLVYGGRQVPRPGFFMEPTVFTDVEDHMYIAKEESFGPVMVISRFKDGDVDGVLARANDTEYGLASGVFTRDINKALYVSEKLEAGTVFVNTYNKTDVAAPFGGFKQSFGKGLDGQEALNEYLKTRATVE

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT87.1
NLMSIM90.0
AACOMP94.7
Seqdif (SeqID)17.1 (XP_031796902.1)
Structdif (F-Target)2.9 (3rhl B)

ProtNLM

NameScore
10-formyltetrahydrofolate dehydrogenase0.521
1.5.1.60.387
Formyltetrahydrofolate dehydrogenase0.056
Methylenetetrahydrofolate dehydrogenase0.003
Aldehyde dehydrogenase 1 family member L10.003
Aldehyde dehydrogenase 1 family member L20.002
Designed by MP, using an AMD MI250 GPU
EC Repo - MI2KF | 310.ai