MI1CA

Prompt

1.3.1.13

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. prephenate dehydrogenase (NADP(+)).

AI Generated Sequence

738 AAs

MSERIALIGLGLIGGSLARRLREAGLDGEIVGYDRDPASRARALELGIADEVTDDAAGAVREADLVILAVPVGAAGAVLAEIAPALAPGAILTDVGSVKGAVARAAAEHLPEGVHFVPGHPIAGTEHSGPEAGFADLFRNRWCVLTPPEGTDPAALAAMREMWRRLGANVEEMDAEHHDRVLAVTSHLPHLIAFSMVGTADDEAETEGEVMSYAAGGFRDFTRIAASDPTMWRDIFLANRDAVLEVLDAFRSDLAALRRAIDRGDGEALFTVFTRGRAVRRSMIEIAGQDAVPVYGRSQDEDPTFLAGPRAIAEIGRRIGVNKDMSHHESILFHALGEITTVGTGFDGAEEALATLADGLDTVTEIGAEDGRVVITGVGHLGLKVPAGEVYLGASGTSIRLAAGLTAAQEDFTLRTGEGSLTKRMPGAIAPRLRWGAETIEAGEGWHCPLMIGGGNKLKGVTYDMPCASASKEVILAIAGGWEGEDTQVVEAPEARRDHERMLARIFGGGEVVEGAVTLSGGEALRAIEEIPAGDISEAEFIVVAAAIAEGADLILEVPVHPGIRTGVVNICRLLGADIAELNERIEAGPEQDLHIVRAGRWLKGIDIPEDHVPLAIDEFPVVFIAACAAEGRTVLTRAEELRVEKEDRIQLAEDGMQALGVEVRETEDGIVIEGQGIAGGGEVAASGDRIAMAFSTAAALARARTIRIGDANRLANTFPNFAALAEEAQRLIAEEAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	75.0
NLMSIM	70.0
AACOMP	88.8
Seqdif (SeqID)	48.4 (WP_263864922.1)
Structdif (F-Target)	12.0 (1rf4 A)

ProtNLM

Name	Score
1.3.1.12	0.399
Prephenate dehydrogenase	0.348
Bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase	0.035
1.3.1.43	0.027
Prephenate dehydrogenase/arogenate dehydrogenase family protein	0.025
3-phosphoshikimate 1-carboxyvinyltransferase	0.020