MHX00

Prompt

1.3.1.48

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. 15-oxoprostaglandin 13-reductase.

AI Generated Sequence

328 AAs

MIKAKTITLKRGFEGFPKENDFELKEVELPELKEGEVLLAELYLSVDPYMRPCMRKLEEGDTMIGAQVSRVVESKNPAFPVGTYVLATFGWQTHSILDGKGLEKVLPWDPKDPLSLALGTIGMPGLTAYFGLLEICGVKEGDTVLVNAAAGAVGSLVGQIAKLGKCKVVGIAGSDEKVAWLKELGFDEAVNYKTVKNLAEALKEASPEGYDCYFDNVGGEFSNAVIPQMKNFGRIAICGAISQYNDTTPPKPGPPPEIIIKQLRMREGFIVRHRGDVREGFKKQLMKWVSEGKIKIKEHITEGIENMPAAFIGLMKGENIGKQIVKVA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	89.9
NLMSIM	90.0
AACOMP	91.1
Seqdif (SeqID)	29.2 (XP_037666846.1)
Structdif (F-Target)	2.6 (1v3t B)

ProtNLM

Name	Score
1.3.1.74	0.191
15-oxoprostaglandin 13-reductase	0.178
Prostaglandin reductase 1	0.151
NAD(P)H-dependent alkenal/one oxidoreductase	0.133
Dithiolethione-inducible gene 1 protein	0.125
Leukotriene B4 12-hydroxydehydrogenase	0.124