MHIU2

Prompt

1.1.1.81

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. hydroxypyruvate reductase.

AI Generated Sequence

323 AAs

MKPSVVLYKALPDDLHQRLAEHFTVHQVNGLTPETRPELLAALAEAEGLIGSGEKIDQAFLEKAPKLRAASTISVGYDNFDVDALSARGIVLMHTPTVLTETVADTMGALMLATARRVVELAERVKAGEWTESIGPDWFGCDVHHKTLGIVGMGRIGMALAQRAHFGFGMPILYTSRRPHPAAEKRFGARYCSLDTLLAEADFLCITLPLTDETHHLIGREQFAKMKSSAILINAGRGPVVDEQALIAALQDGTIHAAGLDVFEQEPLPVDSPLLTLKNVVALPHIGSATHETRYNMAACAVDNLINALTGTVKENCVNPQVK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	95.5
NLMSIM	85.0
AACOMP	94.3
Seqdif (SeqID)	13.0 (WP_050093702.1)
Structdif (F-Target)	5.5 (2dbq A)

ProtNLM

Name	Score
1.1.1.79	0.378
Glyoxylate/hydroxypyruvate reductase B	0.363
1.1.1.81	0.240
Gluconate 2-dehydrogenase	0.003
D-glycerate dehydrogenase	0.003
Bifunctional glyoxylate/hydroxypyruvate reductase B	0.002