MH46S

Prompt

1.5.1.20

Oxidoreductases. Acting on the CH-NH group of donors. With NAD(+) or NADP(+) as acceptor. methylenetetrahydrofolate reductase [NAD(P)H].

AI Generated Sequence

500 AAs
MTITDLIDRARAGRTFVSFEIFPPKTEGEVENLYRRIDEMEWFDPVFVNVTWGAGGSHRDLSTALCTKLQNDYRIEPVAHLTCVDKTRTGLEADLLGLYWAGVRNLLALRGDPPRDGEAWQATHPDFEYATSELVQLIKEMGNDPHFCIGVAGYPEGHPESPNLETDIYHLKEKVDAGAQFIITQLFFDVDKYIDFVRRCRAAGITIPIIPGIMPITNFKLLSRMAPLSNVHIPDSLAARLEPAKDDPAAVRQVGIKWAIEMCERLMAAGVTGCHFYTMNLSEATPAILENLKLWPRPVPHEVAQQPLPWAPSHGPRRVEDTVPAIFERSRNRSYVRTGEDWEFPNGRWGDASSPAFGELDGYGPTYIPSKTEEAIRLWGLPTLQEIFDTLFRCLHGQIRTLPWDLDRPAPETAAIAEEVERVNRGGYWTIASQANADGKSSDDPIYGWGPNGYVYQKAFLEFFVAPELAERLVPKLEKEPNLRFFNHDPNSGTLLAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT71.6
NLMSIM70.0
AACOMP94.3
Seqdif (SeqID)52.7 (KAI8805676.1)
Structdif (F-Target)3.5 (7th5 B)

ProtNLM

NameScore
1.5.1.200.659
Methylenetetrahydrofolate reductase0.260
5,10-methylenetetrahydrofolate reductase0.075
Methylenetetrahydrofolate reductase (NAD(P)H)0.001
Methenyltetrahydrofolate cyclohydrolase0.000
MTHR0.000
Designed by MP, using an AMD MI250 GPU