MH2MT

Prompt

1.14.11.48

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. xanthine dioxygenase.

AI Generated Sequence

499 AAs
MASLTFNVNGQPVTVPDTPPELTLLDYLREKVGLCGTKGGCGGGGCGACTVMVSRYHPATKKITHFAVNACLAPICSLHGWAVTTVEGVGNSQTGLHPVQERIAKCHGSQCGFCSPGMVMSMYALLRNQPEPTMEQIEDSLAGNLCRCTGYRPILDGFKSFAVDSGCQQGKANGVCCLDQDVDLSGDKEKVTLSSLYAAVEFQSYDTSQEPIFPPELLRRAKDMPKKTLVFCGERVTWFKPGNLDELLALKAAHPKAPVVVGNTAVGPEMKFKHVNFPVILAPARIPEMSAVTHGDNGLIIGAACPLSQLVDTLTESVAALPASKTECYGAAQQQLRWFAGPQIRNVASLGGNIIIHKSISDLNPVMDVANCALNLIAMKGKRRIQVNQEMFVGYGKNDLMPEEILESVSIPWSTKGEWFSAFRQASRQPNSAPIINAGMRVTFEEGTDEIKDLSIAYGGAGPTTVLASATCEKLVGRHWNEEMLQEACRLGLKEIYLP

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT87.3
NLMSIM60.0
AACOMP95.2
Seqdif (SeqID)37.7 (NWT12297.1)
Structdif (F-Target)12.2 (1jrp G)

ProtNLM

NameScore
Xanthine dehydrogenase0.449
1.17.1.40.150
Xanthine oxidase0.134
Xanthine dehydrogenase/oxidase0.065
1.17.3.20.064
Xanthine oxidoreductase0.053
Designed by MP, using an AMD MI250 GPU