MGGCZ

Prompt

1.1.1.189

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. prostaglandin-E2 9-reductase.

AI Generated Sequence

394 AAs
MTTRRVVLSAPRPHGVPVADNFRLETVDLPDVAPGQVLVRTLYLSVDPYMRCRMNEDTGSYLSPWALGEVVAGGGVGRVVESRHPGLAPGDFVTSFAWPWQTHAVLDGAGLEKVDPQLHGHPLSYLAGIAGMPGLTAYAGLLDIGAHPGQTMVVVSGAAGAVGSLVGQIGKIKGCSRVVGIAGTDEKCALLTSELGFDAAINYKTGDFAAELRRACPDGVDVYFDNVGGDIADAVISQMNEHARIILCGQISQYNKDVPPPPPPNPAAIIKERNLTREGFLVMNYMDRYEPGILQLSQWISEGKLKVKETVVNGLENMPGAFMGMMKGENIGKQIVKVSDEVLNAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT91.7
NLMSIM70.0
AACOMP87.4
Seqdif (SeqID)30.9 (XP_004371082.1)
Structdif (F-Target)4.8 (2w98 A)

ProtNLM

NameScore
1.3.1.740.194
15-oxoprostaglandin 13-reductase0.180
PKS_ER domain-containing protein0.164
Prostaglandin reductase 20.113
1.3.1.480.076
NADP-dependent oxidoreductase0.053
Designed by MP, using an AMD MI250 GPU