MGDRJ

Prompt

1.1.1.51

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. 3(or 17)beta-hydroxysteroid dehydrogenase.

AI Generated Sequence

621 AAs

MVLLLLLLLLLLLLLYCLRKLLLCCLLLLLLLLLLLLLKPLLLYSLMGEWAVVTGASDGIGKAYSFELARRGLNVVLISRTLEKLQQVASEIEETTGQSVKVIQADFTKDDIYGCIEKKLRGLEIGILVNNVGMLNPLHCSFLNTDEEINNIIHCNITSVVQMTKMVLPEMKKRKKGLILNISSGVGAFSWPLYSLYSASKAFVRTFSQGLQAEYKAKGIIIQAVSPYAVSTPMTGYLNTNTIKTAEEFFKSTMYVTLEGDCVGQTLHRILNGILDLLQGMPFLSSASAHPFVVFLLHRLYKERSVRHALWLNLLGILLLLLKQTLFSKLFSYLHRMLPNAQGYGDVDLYLPVLSKLSKNLVLVTGASDGIGKAYSFELARQGLNVVMISRTLEKLEQVASEIEETTGQSVKVIQADFTKDEIYGYIEKKLQSLEIGGILVNNVGLLNPLHCQFLNTDIEINSVINCNITSVVKMTKMVLPEMEKRKKGLILNISSGVGAFSWPLYSLYSASKAFVRTFSQGLQAEYKAKGIIIQAVSPYAVSTPMTGYLKTNTITTTEEFFKTEMYTVLTGECGQTLYHILLNPILDLLGMPWFGSTASQFPVVFSLLLRVYKHRIRVAL

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	78.1
NLMSIM	85.0
AACOMP	89.9
Seqdif (SeqID)	34.8 (XP_032979430.1)
Structdif (F-Target)	27.4 (2et6 A)

ProtNLM

Name	Score
Hydroxysteroid 17-beta dehydrogenase 3	0.517
Hydroxysteroid (17-beta) dehydrogenase 3	0.120
Hydroxysteroid 17-beta dehydrogenase 12	0.088
Estradiol 17-beta-dehydrogenase 12	0.028
1.1.1.62	0.019
Testosterone 17-beta-dehydrogenase 3	0.015