MG5NO

Prompt

2.3.3.13

Transferases. Acyltransferases. Acyl groups converted into alkyl groups on transfer. 2-isopropylmalate synthase.

AI Generated Sequence

548 AAs

MKNPSKYPPFIPVNLPDRTWPNKVITKAPIWCSVDLRDGNQSLIPPMGVEEKLKMFKLLVDIGFKEIEIGFPSASQTEYDFCRKLIEKNLVPDDVTLQVLTQAREDLIKRTFESLKGAKNAIVHVYNSTSVLQRMVVFNKDKEGIKKIAVKGAKLVKDLTAKYPETNIVFEYSPESFTGTELDYAVEVCNAVMEIWKPTEENKMIINLPATVECATPNVYADQIEWMSRNLNNRENVIISLHTHNDRGTGVACAELGMLAGGDRVEGTLLGNGERTGNVDIVTLALNMYTQGIDPNLDFSNINEIKEVYEESNQMKVHERHPYAGKLVFTAFSGSHQDAISKGMQAIQEKNNTIWEVPYLPIDPKDVGRTYEAVIRINSQSGKGGVAFIIEQAYGYNKLPKMQIEFGKVVQPKTDSEGKELNSEEIYNLFEETYLPVNAPIKFLNFVHFTNEDDKIRIEAEIINNNEEKIISGKGNGPLSALANALKNYFNIDLSVKDYSEHSLSQGSNSKAISYVELKYNGKKVWGVGIDTDIITASIKALFSAVNK

Ligand/Cofactor

acetyl-CoA

CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O

Validation Metrics

PLDDT	87.5
NLMSIM	85.0
AACOMP	91.4
Seqdif (SeqID)	35.9 (WP_168830456.1)
Structdif (F-Target)	10.5 (6ktq B)

ProtNLM

Name	Score
2-isopropylmalate synthase	0.263
2.3.3.13	0.257
Alpha-IPM synthase	0.246
Alpha-isopropylmalate synthase	0.229
Isopropylmalate isomerase	0.000
Pyruvate carboxyltransferase domain-containing protein	0.000