MG0UF

Prompt

1.14.19.59

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. tryptophan 6-halogenase.

AI Generated Sequence

298 AAs
MSKKKIIIIGGGTAGWMTAAALLSKLGKKDVNILIESEIIGTVGVGEATIPPISKFNKLLGIDEEEFCRTTQSTFKLGIQFENWDYKGESYVPHFGTFGKDIGSDQFHHFWLQAKKEGFAPGLDYSCVPCAAAQGKFLSKNNNPDLSNIAYHYHFDADLYAKFLRRYAEEKGVRRVEGKIEAVRHHDGLISSTLELEDGELLKAGDFFCDCTGFRALLIEKTLGPVFDEWSHWLPCDRAIAQCPTYEGEVPYRTTIATKAGWQWCIPLQQRTGNGYVYSSRFLHDEEAQRLLVQNVSV

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT82.7
NLMSIM80.0
AACOMP93.9
Seqdif (SeqID)44.1 (RYY02841.1)
Structdif (F-Target)9.7 (6y1w B)

ProtNLM

NameScore
Tryptophan halogenase0.796
Tryptophan 7-halogenase0.137
1.14.19.90.019
Flavin-dependent tryptophan halogenase RebH0.006
Tryptophan halogenase,0.005
Tryptophan 5-halogenase0.003
Designed by MP, using an AMD MI250 GPU