MFT08

Prompt

1.14.11.32

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. codeine 3-O-demethylase.

AI Generated Sequence

292 AAs
MEEVKKASEKWGFFQVVNHGIPLELMEKMKEATKEFFELPLEEKKKYAKDPKSGFEGYGSKLQFAEAKELDWKDTYFLHHPVPSNRDYSPIPSDPNQIWPENPKGFREIMEEYAKEVKKLAVKLLEVLSENLGLEKGYFKKAFGGENQYTLKVNHYPPCPQPDLTLGVRPHTDPGLITLLYQDQVGGLQVLKDGKWIDVPPIPNALVVNIGDQLEILSNGKYKSVLHRAVVNKEKERMSIATFYNPKLDAVISPAPELVEEENPKLYKPFTIKDLVKGGEKVPQVKQVPQIK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT88.1
NLMSIM70.0
AACOMP87.8
Seqdif (SeqID)46.5 (KAK4418931.1)
Structdif (F-Target)9.8 (6lsv B)

ProtNLM

NameScore
Fe2OG dioxygenase domain-containing protein0.559
1.14.11.610.033
Oxoglutarate/iron-dependent dioxygenase0.032
1.14.20.60.031
1.14.11.230.018
1.14.11.90.015
Designed by MP, using an AMD MI250 GPU