MFNIT

Prompt

1.3.1.14

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. dihydroorotate dehydrogenase (NAD(+)).

AI Generated Sequence

547 AAs

MLYRLARPALFSLDPERAHELTIRALDRASRTPLLRLIAPDDPRLPVQVAGLTFPNPVGLAAGLDKNGEAIDALMALGFGFVEVGTVTPRPQPGNPKPRLFRLVEDEALINRMGFNNLGVDNLVANVRRARYRGVLGINIGKNKDTPVERAVDDYLICMEKVYPYASYIAINISSPNTPGLRSLQYGEALDDLLAALKDRQRELAERHGKRVPVFVKIAPDLSEEELDQVADSLVRHKIDGVIATNTTLDRELVQGLRHADEAGGLSGRPLQARSTEVIRRLRLELGGRLPIIGVGGIDSGVAAREKIAAGASLVQIYTGLIYRGPGLIEDIVKGLIARLERDGFGSIAEAIGVDTHAWRAALIAPAPALARRRLGLLLGLLLLLLLGALALAGLVRLRRGERLVEHTERELAEARRLAEDLPDEKALTEHLDVVGLDRPEPQPEPLLPGQPTPRLAATIEVVRRLREIRAREGLVGEPVQQLIADRDNIGGEGDTQLIYDRIAPLAAAREIDPDGRAIYAEAPTLLGAGLDKLDLQAIVASLKDRH

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	78.5
NLMSIM	60.0
AACOMP	89.9
Seqdif (SeqID)	23.5 (WP_084934692.1)
Structdif (F-Target)	2.6 (7t6h B)

ProtNLM

Name	Score
DHOdehase	0.215
1.3.5.2	0.195
DHODase	0.170
Dihydroorotate oxidase	0.164
DHOD	0.127
Dihydroorotate dehydrogenase (quinone)	0.119