MFCIZ

Prompt

2.3.1.161

Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. lovastatin nonaketide synthase.

AI Generated Sequence

992 AAs
MDPQQRLLLEVAWEALEDAGIPPERLRGSDTGVFVGMCSNDYGSLLLEGLPGIEAYTATGNLASVLANRVSYFLGLRGPSMAVDTACSSSLVAVHLACQSLRSGECDMALAGGVNLMLTPGTFVEFSKAGALSPDGRCKAFDASADGYGRGEGCGVVVLKRLSDALRDGHRILAVIRGSAVNQDGRSKGLTAPNGPSQQRVIRQALQNAGVSPETVDYVEAHGTGTTLGDPIEARALGTVYGRGRPAERPLLIGSVKTNIGHTEAAAGVAGLIKTVLAMHHGVIPPTLHFDKPNPHIDWEKLRVRVPTEAQPWERTGHPRRAGVSSFGFGGTNAHVILEQAPPPEPAPAPEPRPAHLLPLSARSEAALRAQAGRLAEWLEGHPELPLADVAYTLATGRSHFEHRAAVVGHDREELLAGLRALAAGEAAPGVVRGAAGGKPVAFVFSGQGSQWPGMGRELYEAEPVFRAAVEECDALLRPLVGWSLVDVLYGEAEELNRTEVTQPALFAVQVALARLWESWGVRPDAVIGHSVGEIAAAHVAGVLSLEDGVRLVAYRSRLMQALPGQGAMVAVGLAEEEVAPLIAGYPGVSIAAVNSPQSVVLSGEVEAVEAVAAEWEAQGVRTRRLRVSVAFHSPLMDPILAEFREALAGLTPRPPRIPVYSTVTGELIDTEALDAGYWARNLRQPVRFAEAVRTLAAEGHRVFLEVGPHPVLSHSIAETLEGAGVEAVGTLRRGQEEVDTFLASVGQLHCRGVAVDWAGFYGGGRRRVDLPTYPWQRERYWLPAPAAAAAAAAGLQAGGHPLLGARVELAGTDGVVLQTRLSLSTQPWLADHRVHGAVVLPGAAYVEMALAAARERVAAVLGHEAEEIDPRDFPLGLAALEGLREAGVEVVAVHGAGEVAAALAAGELSLEEAVRLVAARSRLMQALPGGGAMLAVGLPAEEVEALLAERGVEVSAINGPRSVVLSGEAEAVRALVEELEAAGFAPAELEA

Ligand/Cofactor

NADPH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)O)O)O)O

Validation Metrics

PLDDT85.6
NLMSIM60.0
AACOMP89.0
Seqdif (SeqID)42.2 (HEV3290804.1)
Structdif (F-Target)11.5 (8ee1 A)

ProtNLM

NameScore
SDR family NAD(P)-dependent oxidoreductase0.180
Polyketide synthase0.158
Acyltransferase domain-containing protein0.140
Carrier domain-containing protein0.092
Acyl transferase domain-containing protein0.081
Type I polyketide synthase0.066
Designed by MP, using an AMD MI250 GPU