MF6TW

Prompt

2.3.1.161

Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. lovastatin nonaketide synthase.

AI Generated Sequence

500 AAs

MAAVAGALSLEDALRLVAARGRLMQRLPGGGAMLAVGLPAEEVAPLLAGHGGLAVAAVNGPRQTVVSGPAAAVEAVAARWEAEGRFARRLPVDHAFHSPLMEPILAEFRAALAGLTPRPPRIPFVSNVTGAPLDPAALDADYWARNLRRPVRFADAVRALAADGVRTFLEVGPHPVLTQAIAETLAAAGDAAAVVGTLRRDGDEVRTFLTSLGRLHVAGVPVDWRAFYPGGGRRRVDLPTYPFQRRRYWLDTPAAADAAAAGLGADAHPLLGHRVELPGADRHVFETRLSLSTAPWLADHVVHGAVVLPGTFVEMALLRAVREQGCASVLGHSPDEIGLDPNLALELAGRGLAPDGRCKAFDAAADGYGRGEGCGVVVLKRLSDARRDGHRVLAVIRGSAVNQDGRSNGLTAPNGPAQERVIRQALANAGLAPADVDYVEAHGTGTPLGDPIEAQALATVYGRGRPADRPLWLGSVKTNIGHLEAAAGVAGFIKMVLAMR

Ligand/Cofactor

NADPH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)O)O)O)O

Validation Metrics

PLDDT	77.2
NLMSIM	60.0
AACOMP	86.7
Seqdif (SeqID)	59.6 (WP_252485058.1)
Structdif (F-Target)	27.1 (7akc A)

ProtNLM

Name	Score
SDR family NAD(P)-dependent oxidoreductase	0.206
Carrier domain-containing protein	0.169
Polyketide synthase	0.104
Acyl transferase domain-containing protein	0.060
Acyltransferase domain-containing protein	0.057
Type I polyketide synthase	0.057