MEW23

Prompt

1.14.11.7

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. procollagen-proline 3-dioxygenase.

AI Generated Sequence

703 AAs

MRLLLLLLLPLLLPAAAPPRPEELPLPPFDLLYAEGVAAYYRGDWQGAVRLMERALRSRARLRAIRTRCATRCAADHPAALGDLRFFAALLRRAACLDQCLGEPAARHRVSEEVRLDFQRRVSYDRYVPYNYLQRAYIQLNKLEKAAAAAHTFFVANPEHMEMRQNIDQYRMTAGVEKSSLFDLEAKPHMESYSAGVRLYEKEEFELAIPFLEQALQEYFAEDIECRALCEGPQEFEEYEYLGYKAGLYEAIADHYMQVLACQHDCVRELATSPSGRSPIENFLPLHYDYLQFAYYRVGDYTKALECAKSYLLFHPDDEDVLENAGYYTEMLLDETDPASIKPREEAETYLLRHKLESHLISFAAEGLGFGYTEPNYWTERVGPLREDNHGPVSEPVRISNDIGGEPMEIHSLSVKKKSLPKIDRLKREGGPLLYGDIKFVYNSEQLNGTQRVFLDNVVSDEECRELHSLASGIMLAGDGYRGKTSPHTPNEKFEGATVFKALKLGYEGRVPLKSARLFFDISEKARRIVESYFMLDSTLHFSYTHLVCRTAISEQQERNDLSHPIHADNCLLDPAANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPQCGRAISFSSGGENPHGVKAVTKGQRCAVALWFTLDPLHSELERIQADEVIAMLFEEHGMEHSLNINPKDEESPPPQEEL

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	75.9
NLMSIM	90.0
AACOMP	92.9
Seqdif (SeqID)	25.7 (XP_025142346.3)
Structdif (F-Target)	19.3 (4j25 E)

ProtNLM

Name	Score
Procollagen-proline 3-dioxygenase	0.658
1.14.11.7	0.278
Prolyl 3-hydroxylase 2	0.037
P3H2 hydroxylase	0.012
P3H1 hydroxylase	0.002
Prolyl 3-hydroxylase 1	0.001