MEN6P

Prompt

1.14.11.2

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. procollagen-proline 4-dioxygenase.

AI Generated Sequence

536 AAs

MKLWLSLLLLAWGGVLGSAQGELFTSIGQMTDLIYTEKDLVQSLKEYIRAEEAKLAKIKSWAEKMERLTSKSTADPEGYLAHPVNAFKLVKRLNTEWPALENLVLQDMAAGFISNLTVQRQFFPTEEDQTGAAKALMRLQDTYKLDTDTLSKGNLPGTKYQSMLSVEDCFEMGRSVYNEGDYYHTLPWMEQALKQLEEGEVSTATKAQVLDYLSYAVFQLGDIHRAMELTRRLLSLDPSHERAGGNLRYFERLLAEKEEKELSNQTVTDLPEQTGIYERPVDYLPERDQYEMLCRGEGVKMTPRRQKRLFCRYHDGNRNPQLLIAPFKEEDEWDSPHIVRFYDVMSDDEIEKIKELAKPKLARATVRDPKTGVLTVASYRVSKSSWLGEDDNPVVARVNRRMAHITGLTVSTAELLQVANYGVGGQYEPHFDFSRKDESDAFKRLGSGNRVATFLNYMSDVEAGGATVFPELGASIWPKKGTAVFWYNLFKSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGTSEVDA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	89.2
NLMSIM	90.0
AACOMP	94.9
Seqdif (SeqID)	14.6 (XP_034511874.1)
Structdif (F-Target)	3.9 (7zsc A)

ProtNLM

Name	Score
Procollagen-proline 4-dioxygenase	0.563
1.14.11.2	0.417
Prolyl 4-hydroxylase subunit alpha-2	0.007
Prolyl 4-hydroxylase subunit alpha 2	0.003
P4Hc domain-containing protein	0.003
P4HA2 hydroxylase	0.001