MELPV

Prompt

2.3.1.119

Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. Transferred entry: 1.1.1.330, 1.3.1.93, 2.3.1.199 and 4.2.1.134.

AI Generated Sequence

500 AAs
MDPQQRLLLEVAWEALEDAGLAPGALRGSRTGVFVGVANNDYGRLLLGDLPGVDGYLATGNAKSFAAGRLSYLLGLRGPSLTVDTACSSSLVAVHLACQSLRSGECDLALAGGVNLLLTPGTFVGFSQAGMLSPDGRCKAFDASADGYGRSEGVGMVVLKRLSDALADGDRILAVIRGSAVNQDGASNGLTAPNGPSQAAVIRQALAAAGLAPADVGYVEAHGTGTALGDPIEAQALGAVFGRGRDAGRPLWLGSVKTNIGHLEAAAGVAGVIKVVLSLHHGVLPPTLHFAEPSPHIDWAALPVRVLTEARPWPAGGRPRRAGVSSFGVSGTNAHVVLEQAPAPAPAAAAAPAPALLPLSARTAAALRAQAGRLAAHLAAGPGAALADVAHTAATGRSAFAHRAAVVGADRAALAAGLAALAAGEPAGVVTGAAGGGRPVAFLFTGQGSQWVGMGRELYAAEPVFAAALDACAAALAPHLDRSLVDVLLGGGGGGGGGGG

Ligand/Cofactor

acetyl-CoA

CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O

Validation Metrics

PLDDT92.5
NLMSIM60.0
AACOMP84.5
Seqdif (SeqID)44.2 (WP_159060994.1)
Structdif (F-Target)18.0 (6mhk B)

ProtNLM

NameScore
Type I polyketide synthase0.157
Beta-ketoacyl synthase0.120
Carrier domain-containing protein0.117
SDR family NAD(P)-dependent oxidoreductase0.114
Acyltransferase domain-containing protein0.097
Acyl transferase domain-containing protein0.075
Designed by MP, using an AMD MI250 GPU