MEJC2

Prompt

1.13.11.39

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. biphenyl-2,3-diol 1,2-dioxygenase.

AI Generated Sequence

303 AAs
MSIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGADPGALYLRMDDFPARLVVVPGEHDRLVEAGWEAANAEGLQEIRNRLEAAGTPFKEATAEELADRRVEEMIRFSDPSGNTLEVFHGAALEHRRYVSPYGHRFVTGEQGMGHVVLTRDDDESALHFYRDVLGFRLRDSMRLPPQMVGRPADGPALWLFFHGCNPRHSLAFLPMPTPSGIVHLMVEVENADDVGLCLDRALRRKVPISATLGRHVNDKMLSFYMKTPGGFDIEFGCEGRQVDDDDWIARESTAVSLWGHDFSVGTRSGLFT

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT86.3
NLMSIM70.0
AACOMP92.3
Seqdif (SeqID)10.7 (WP_220019805.1)
Structdif (F-Target)3.9 (2zi8 A)

ProtNLM

NameScore
2,3-dihydroxybiphenyl 1,2-dioxygenase0.432
1.13.11.-0.123
Iron-dependent extradiol dioxygenase0.101
Extradiol dioxygenase0.079
Biphenyl-2,3-diol 1,2-dioxygenase0.061
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase0.040
Designed by MP, using an AMD MI250 GPU