ME7SW

Prompt

1.1.1.346

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming).

AI Generated Sequence

329 AAs

MKVTYEQLKAGFNRVLISRGVVNETADECAEAFADATEAGVYSHGVNAFPKFIEQLENGDIIPDAQPKRITSTGLIEQWDAQRSIGNLTAKEMMDRAIELAADVYIGLVALRNANHWMRGGSYGVQAAEKGYIGICWTNSIAVAMPWGAKECRIGTNPLGVAIPSTPITMVDMSMSMFHYGMLEVYRLAGRQLPVDGGFDDEGNLTKETGVIGPKNRILPMGYWKGSGMSIVLDMIATLSENGASVAEVTRQDNDEIGISQIIWAIEVDKLINGPTTDAKLQQIMDYVTTAERADENYQIRLPGHEFTKLLAENRRHGITIDDSVWAKQ

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	89.9
NLMSIM	70.0
AACOMP	93.4
Seqdif (SeqID)	13.7 (WP_206355964.1)
Structdif (F-Target)	3.8 (1s20 E)

ProtNLM

Name	Score
1.1.1.130	0.264
2,3-DKG reductase	0.248
2,3-diketo-L-gulonate reductase	0.236
3-dehydro-L-gulonate 2-dehydrogenase	0.228
2,3-didehydrogluconate reductase	0.003
1.1.1.350	0.002