ME0UW

Prompt

1.6.3.2

Oxidoreductases. Acting on NADH or NADPH. With oxygen as acceptor. NAD(P)H oxidase (H2O-forming).

AI Generated Sequence

500 AAs

MNNWLLNEGLSRIFLVAWLGLNIFLFVYTFWIYDEEEKYFYTRRILGSALAWARAPAAVLCFNCMLILLPVCRNLISFLRGTSACCARRLRRQLDKNLTFHKMVAWMIAFNTAIHTIAHLFNVERYHRARVQNNEDLSAVLSELGEKPNESYLNPIRRFNEGVTGGVYVFTRIAGITGVVITLALILIITSSTEFIRRSYFEVFWYTHHLFVIFFIGLAIHGAGRIVRGQTPESLRAHNPVFCDRHYADWGRIADCPVPQFAGNPMATWKWVIGPMLLYLCERLIRVWRSQQKVVITKVTTHFKTVLELQMKKKGFKMEVGQYIFINCPSISKLEWHPFTLTSAPEEDYFSIHIRAIGDWTEGLFKAFGCEKQEEALEWPRIAVDGPFGTASEDVFQYEVAMCVAAGIGVTPFASILKSIWYKCHNANSTLRTKKIYFYWLCRDTHAFEWFADLLLQLEHQMQERGNADFLSYHIYLTGWDESQANHFAVHWDEKRDVIT

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT	88.2
NLMSIM	85.0
AACOMP	93.6
Seqdif (SeqID)	25.4 (ELK07153.1)
Structdif (F-Target)	14.1 (8gz3 B)

ProtNLM

Name	Score
NADPH oxidase 3	0.348
Cytochrome b-245 heavy chain	0.263
FAD-binding FR-type domain-containing protein	0.194
Cytochrome b-245 heavy chain-like	0.039
NADPH oxidase 1	0.028
Superoxide-generating NADPH oxidase heavy chain subunit A	0.006