MD016

Prompt

1.2.1.27

Oxidoreductases. Acting on the aldehyde or oxo group of donors. With NAD(+) or NADP(+) as acceptor. methylmalonate-semialdehyde dehydrogenase (CoA acylating).

AI Generated Sequence

499 AAs
MTEITHFINGEHVEGKSGRFADVFNPATGEVQARVALASAAEVDAAVANAKAAQPGWAAWSPQRRARVMFKFVELLNREMDELAELLSREHGKTEADALGDVQRGLEVVEFACGIPHLLKGEYSEQAGPGIDVYSMRQPLGVCAGITPFNFPAMIPMWKAPIAIACGNAFILKPSERDPSVPLRLAELWMEAGLPAGVLNVVNGDKEAVDAILDHPDVKAVGFVGSTPIAQYIYTRASANGKRAQCFGGAKNHMVIMPDADMDQAVDALMGAGYGSAGERCMAISVAVAVGDKTADRLMAKLVPQIEALKVGPGTDPGSDMGPLVTAEAKERVEGYIASGVKEGAELEVDGRGFKAQGYENGFFVGGTLFDHVTPDMKIYKEEIFGPVLSVVRAESYEEGLRLANDHEYGNGTAIFTRDGDTARDFASRVNVGMVGVNVPIPVPVAYHTFGGWKASGFGDLHAHGPDGVRFYTRTKTVTSRWPSGIKEGAEFNIPTMKS

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT92.7
NLMSIM95.0
AACOMP92.2
Seqdif (SeqID)22.9 (MBX3534759.1)
Structdif (F-Target)1.4 (4zz7 G)

ProtNLM

NameScore
CoA-acylating methylmalonate-semialdehyde dehydrogenase0.318
Methylmalonate-semialdehyde dehydrogenase0.190
1.2.1.270.151
Methylmalonate-semialdehyde dehydrogenase (CoA acylating)0.145
Methylmalonate-semialdehyde dehydrogenase (Acylating)0.044
Methylmalonate-semialdehyde dehydrogenase [acylating]0.039
Designed by MP, using an AMD MI250 GPU