MCZZL

Prompt

1.13.11.2

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. catechol 2,3-dioxygenase.

AI Generated Sequence

308 AAs
MSGILRLGHVQIRVLDMAAAREHYVDLLGMIEIERDDENRVYLKAWDEYDKHSVILREADDPGADYMGFKVATEDDLARKVADLAAYGCAVERLPAGELAGCGRRMRFQSPSGHHFELYAEKEYTGKGWVGENPNPAWPRGDLGMGAVRFDHCLLYADDPARVYELFTEVLGFRLTEQQVLDPDGRPIALFWCLSSKAHADVAFIGHPGGRLHHVSFWLETWNDVLRAADLISMTDTSIDIGPTRHGLTRGKTIYFFDPSGNRNEVFCGGEYVYPDHPKVTWTAEDLGKAIFWHDRTLNREFMSVVTG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT83.1
NLMSIM85.0
AACOMP93.1
Seqdif (SeqID)27.8 (WP_019752929.1)
Structdif (F-Target)5.3 (1mpy D)

ProtNLM

NameScore
1.13.11.20.357
Catechol 2,3-dioxygenase0.231
Metapyrocatechase0.200
CatO2ase0.195
3,4-dihydroxyphenylacetate 2,3-dioxygenase0.001
Manganese-dependent 2,3-dihydroxybiphenyl 1,2-dioxygenase0.001
Designed by MP, using an AMD MI250 GPU