MC1IG

Prompt

1.5.1.53

Oxidoreductases. Acting on the CH-NH group of donors. With NAD(+) or NADP(+) as acceptor. methylenetetrahydrofolate reductase (NADPH).

AI Generated Sequence

288 AAs

MKLLESGKTFSFEFFPPKTEGGAVNLYRTIRDLAPLAPDFVSVTYNAGGSTRERTIEVVAEIQRETGLEPVAHLTCVGRSRAELQDILDRYWAAGIRNVVALRGDLPSGMEAFTPHPDFRYASELVEFIRAEPDFHIVGAAYPEGHPESPDLDLDIEHLKRKVDAGATFAITQLFYDVDTYFRFVDRCRALGITVPIIPGIMPITNLKQLKRFSELCGASLPRWIKRRLEGYGDDPEAVREAGIEYATEQCRDLLAGGAPGLHFYTMNRSALTLEIWRNLGLLHREKV

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	93.4
NLMSIM	90.0
AACOMP	94.1
Seqdif (SeqID)	39.7 (HHO68866.1)
Structdif (F-Target)	5.6 (7th5 B)

ProtNLM

Name	Score
1.5.1.20	0.555
Methylenetetrahydrofolate reductase	0.441
Methylenetetrahydrofolate reductase (NAD(P)H)	0.001
Methylenetetrahydrofolate reductase [NAD(P)H]	0.001
5,10-methylenetetrahydrofolate reductase	0.001
Methenyltetrahydrofolate cyclohydrolase	0.000