MBUV0

Prompt

1.14.11.33

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. DNA oxidative demethylase.

AI Generated Sequence

214 AAs

MLDGFAEAPPWREPLAPGAWVLRGFALDAAQRLLAEIRAVAAQSPFRHMVTPGGYTMSVAMTNCGALGWTSDRHGYRYAAVDPLTGRPWPAMPPAFRALAREAAAAAGYPGFAPDACLINRYAPGARMSLHQDKDERDFRAPIVSVSLGLPAIFQFGGLTRSDPLRRIALEHGDVVVWGGESRLFYHGVQPLKPGVHPLTGARYINLTFRRAGR

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	95.8
NLMSIM	90.0
AACOMP	88.5
Seqdif (SeqID)	23.4 (MTH46461.1)
Structdif (F-Target)	1.9 (3khc B)

ProtNLM

Name	Score
DNA oxidative demethylase AlkB	0.317
Alpha-ketoglutarate-dependent dioxygenase AlkB	0.245
1.14.11.33	0.157
Alkylated DNA repair protein AlkB	0.083
1.14.11.-	0.035
Alpha-ketoglutarate-dependent dioxygenase	0.028