MAYRV

Prompt

1.14.12.18

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor. biphenyl 2,3-dioxygenase.

AI Generated Sequence

269 AAs
MKIVVLGGGFAGVELAGALHDYHREVLTVSRPNYHVFQPLLPSVATGTVEAHSIDEPPRRKLRRQKHFKFLQGECVGIDKAKKNVTLKSLDESGEKVAYDYLVVAVGSQSNTFGHPGVKENCFPLKEIHDAIEIRNTIMNCFEIASLDLTEEERKRLLTFVIVGGGPTGVELAGALHDYHRTVLPKYFPNVDLHTMNITLIEARPRILPGLGERISKYAEETLDKRGVEVLTNGRVVKVEEDGLVFKDGKEIHRTTMVWATGVKANPFI

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT94.7
NLMSIM85.0
AACOMP92.5
Seqdif (SeqID)53.6 (VAI76046.1)
Structdif (F-Target)8.7 (5kmq C)

ProtNLM

NameScore
Pyr_redox_2 domain-containing protein0.887
FAD/NAD(P)-binding domain-containing protein0.041
NADH dehydrogenase0.004
External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial0.003
External alternative NAD(P)H-ubiquinone oxidoreductase B2, mitochondrial0.002
FAD-dependent pyridine nucleotide-disulfide oxidoreductase0.002
Designed by MP, using an AMD MI250 GPU