MAK3Z

Prompt

1.14.19.17

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. sphingolipid 4-desaturase.

AI Generated Sequence

295 AAs
MEEHPATRRREILAKHPEIKTLFGPDPHTKWVVLGVLVTQLFACYLVKDLSWKWIFFAYAIFGGCINHNLFLAIHEISHNTAFGNSRALNRWFGIFANLPIGVPYSASFQKYHMDHHRYLGVDGLDVDIPTNLEGHFFCTTFGKMFWVFLQPLFYALRPLYVNPKPITRMEIFNTLIQLAFDIVIYYLWGFKPALYLIASTILGCGLHPISGHFISEHYMFLKGQETYSYYGPLNLLTFNVGYHNEHHDFPSIPGSRLPKVKKIAPEYYDNLPQHTSWIKVLWDFVYEDLKDEKK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT88.8
NLMSIM75.0
AACOMP90.5
Seqdif (SeqID)23.2 (NWI89397.1)
Structdif (F-Target)27.0 (8f6t A)

ProtNLM

NameScore
1.14.19.170.550
Sphingolipid delta(4)-desaturase DES10.182
Degenerative spermatocyte homolog 10.135
DEGS1 desaturase0.041
Dihydroceramide desaturase-10.038
Sphingolipid 4-desaturase0.026
Designed by MP, using an AMD MI250 GPU