MA3O2

Prompt

2.1.1.61

Transferases. Transferring one-carbon groups. Methyltransferases. tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase.

AI Generated Sequence

662 AAs
MSSLLPPAQLEFDEDGTPVSRQFGDVYFSSDNGLEETRYVFLQGNRLPERWAELPPGRRFVVAETGFGTGLNFLCTWQAWRDHAPEGARLHFVSVEKHPLSRADLLRAHALWPELAPFAEQLLAQYPAIHPGFHRLLFDDGRVTLTLLFGDALECLPQLDGQVDAWFLDGFAPSKNPEMWTPELFAELARLARPGATFATFTTAGWVKRGLQEAGFKVQKVPGFGHKREMLRGVFGEWLPEPPPPPPPPPPPPPPPPPPPPRRAAVIGGGLAGCATAASLAARGWQVTLLERHDAPAQEASGNPQGVLYPKLSAEHTALSRFISSGFLYTRRLYDLLSRGFDWDHCGVLQLAFDEKSERKQAQMAALAFPEEMVHAVDAAEAERLAGVTLGGGGLYYPEGGWVCPPALCRQALAHPGITLLHHRQVTELRRVEDGWRALADGETLAEADVVVLACGAEIKRFGQSAELPLKRVRGQVTHLPPTPSLARLRTVVCGEGYVTPRPNGEHTLGASFDFRSDLETPTREEDHQNLDLLREISDPLARLAAEELDVSGQLQGRAGFRCTSPDYLPIVGPLADFDAFTETYAVLGKDARPVPDAPCPWLDGLYVNSGHGSRGLCTAPLCGEILASQIDGEPLPLDRASLEACHPNRFLVRKLIKGKAV

Ligand/Cofactor

S-adenosylmethionine

C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O

Validation Metrics

PLDDT91.7
NLMSIM70.0
AACOMP91.1
Seqdif (SeqID)35.0 (AZV28343.1)
Structdif (F-Target)8.2 (3ps9 A)

ProtNLM

NameScore
FAD-dependent cmnm(5)s(2)U34 oxidoreductase0.205
2.1.1.610.194
TRNA (mnm(5)s(2)U34)-methyltransferase0.183
TRNA mnm(5)s(2)U biosynthesis bifunctional protein0.164
TRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC0.156
1.5.-.-0.087
Designed by MP, using an AMD MI250 GPU