MA3DS

Prompt

1.13.11.34

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. arachidonate 5-lipoxygenase.

AI Generated Sequence

500 AAs
MPSYTVTVATGSQWFAGTDDYIYLTLVGTQGCSEKHLLDKPFYNDFERGAVDSYDVTCDKELGEIQLVKLEKRKYWLQDDWYCKYITVKTPAGDYLEFPCYRWITDEGEIVLRDGRAKLPRDDQTLILKQHRRKELETRQKMYRWTEWNPGFPLSIDARCHKDLPRDIQFDSEKGVDFLLNYSKAMENLFINRFMHMFQSWSDFADFEKIFVRISNTISEYVMEHWKEDSMFGYQYLNGCNPVLIRKCTEIPKKLPVTNDMVESFLERGLTLEQELEQGNIFIADYELLDGIDANKTDPCTQQYLAAPICLLYKNAANKIVPIAIQLNQTPGEDNPIFLPTDAKYDWLLAKIWVRSSDFLVHQTITHLLRTHLISEVFSIAMLRQLPAVHPIFKLLVPHVRFTIAINTKAREQLISECGLFDKANSTGGGGHVQLVQRAMKTLTYSSLCFPEDITKRGVIPYYYYRQDGLKVWEAIKSYVTDIVDIYYKSDDAVQEDAEL

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT83.6
NLMSIM75.0
AACOMP93.0
Seqdif (SeqID)16.6 (NWU54364.1)
Structdif (F-Target)5.0 (3v92 B)

ProtNLM

NameScore
LOX5 lipoxygenase0.463
Arachidonate 5-lipoxygenase0.340
ALOX50.061
Polyunsaturated fatty acid 5-lipoxygenase0.010
Arachidonate 5-lipoxygenase-like0.006
1.13.11.-0.003
Designed by MP, using an AMD MI250 GPU