MA2P5

Prompt

1.14.11.33

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. DNA oxidative demethylase.

AI Generated Sequence

216 AAs

MTLDLFADLPQPAPREQLAPGAVVLRGFALPHIEPLLAAIDAIVAQAPFRHMVTPGGFTMSVAMTNCGALGWVTDRHGYRYSAVDPDSGRPWPAMPAAFRALARAAAAEAGFAGFVPDACLINRYEPGTKMSLHQDKDERDFSAPIVSVSLGLPATFLFGGLARSDRPQRVPLVHGDVVVWGGPSRLRYHGVLPLKDGVHPLTGPQRINLTFRKAG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	96.1
NLMSIM	90.0
AACOMP	90.1
Seqdif (SeqID)	27.4 (WP_280813865.1)
Structdif (F-Target)	2.1 (3khc B)

ProtNLM

Name	Score
DNA oxidative demethylase AlkB	0.296
Alpha-ketoglutarate-dependent dioxygenase AlkB	0.202
1.14.11.33	0.117
Alpha-ketoglutarate-dependent dioxygenase	0.085
Alkylated DNA repair protein (DNA oxidative demethylase)	0.064
Alkylated DNA repair protein AlkB	0.054