M9RBF

Prompt

1.3.1.22

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)).

AI Generated Sequence

387 AAs

MEHLLENPLLLLTLWLLAVAAFGGVLLLELVPYGKYHRPPSRLGRVRLPRCAWLLQESPSFVVPCLLLAAGRELLLSLPGQLLLWACFVHYVQRTLIFPLHLRGGRTPFVITFAFAMFCCLSNGLLQMRYLSHYAQYREPTWWVPRFVGGLLMFLGMLWVNIHSDRILRNLRKPGEGIKYPIPGGLFEYVSAPNYFGEIVEWCGCAILTWSLQALALAFFTTVNVLPRARAHHRWYLRKFTDYPESRKELIPFIMLLTFPTFGLPTFLLTTVLFQLKTWAGGRRSCYEEGYFSEYKDLRPALPIPLLPRPTPRLLLLLLLGGVLYWSYALRRMWGSRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	70.8
NLMSIM	70.0
AACOMP	84.7
Seqdif (SeqID)	44.2 (XP_006875031.1)
Structdif (F-Target)	7.1 (7c83 A)

ProtNLM

Name	Score
S5A_REDUCTASE domain-containing protein	0.324
3-oxo-5-alpha-steroid 4-dehydrogenase	0.210
1.3.1.22	0.196
3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+))	0.141
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0.020
SR type 1	0.011