M9QCZ

Prompt

1.13.11.39

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. biphenyl-2,3-diol 1,2-dioxygenase.

AI Generated Sequence

297 AAs
MAIKGLGYLRIEATDMAAWREYGLKVLGMVEGKGAGEAALYLRMDEFRHRLVVVPGEHDRILTVGWEVANAAGLQDLRARLEAAGVPYKELSAAEAADRRVDELITFADPSGNTLEVFHGAALDHRPVVSPYGHRFVTGDQGLGHVVLPTADDAAALHFYTDVLGFRLRDSMRLPPQVGRADGPAVRLFLGCNPRHHSLAFLHMPSPKLIHVLMVELETSDAVGLALDRALRRKVKISATLGRHTNDKMLSFYMKPPGGFDIEFGCEGMQVDDDTWYARESTKASYWGHDFTVGMPR

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT87.9
NLMSIM80.0
AACOMP92.4
Seqdif (SeqID)21.9 (WP_034162428.1)
Structdif (F-Target)3.8 (2zi8 A)

ProtNLM

NameScore
2,3-dihydroxybiphenyl 1,2-dioxygenase0.264
Biphenyl-2,3-diol 1,2-dioxygenase0.200
1.13.11.-0.106
Iron-dependent extradiol dioxygenase0.090
1.13.11.390.065
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase0.061
Designed by MP, using an AMD MI250 GPU