M9HA2

Prompt

1.2.1.27

Oxidoreductases. Acting on the aldehyde or oxo group of donors. With NAD(+) or NADP(+) as acceptor. methylmalonate-semialdehyde dehydrogenase (CoA acylating).

AI Generated Sequence

499 AAs

MTKEIGHFINGKHVAGSSGRFAPVFDPMTGEVQARVPLASKAETDAAVKAAEAAQPAWAATNPQRRARVMMKFVELLNANMDELAELLSREHGKTLADAKGDVQRGIEVIEFAIGIPHLLKGEFTDGAGPGIDMYSMRQPLGVVAGITPFNFPAMIPLWKFGPAIACGNAFILKPSERDPSVPMRLAELMLEAGLPKGIFQVVNGDKEAVDAILTHPDIKAVGFVGSTPIAQYIYGTAAANGKRAQAFGGAKNHMIIMPDADLDQAVDALIGAGYGAAGERCMALSVAVPVGEETADRLVAKLIPRIEKLRVGPSTDAKADYGPVVTAAAKDRVKGYIDIGVKEGAELVVDGRGFKMQGYEDGYFVGGHLFDHVTTDMKIYKEEIFGPVLSVVRAKTYEEALRLPMDHEYGNGVAIFTRDGDTARDFASRVNVGMVGINVPLPVPVAYHTFGGWKRSGFGDLNQHGPDAFRFYTRTKTVTSRWPSGIKDGAEFSIPTMK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	92.4
NLMSIM	85.0
AACOMP	92.2
Seqdif (SeqID)	20.1 (WP_171216413.1)
Structdif (F-Target)	1.6 (4iym C)

ProtNLM

Name	Score
CoA-acylating methylmalonate-semialdehyde dehydrogenase	0.293
Methylmalonate-semialdehyde dehydrogenase	0.220
1.2.1.27	0.142
Methylmalonate-semialdehyde dehydrogenase (CoA acylating)	0.133
Methylmalonate-semialdehyde dehydrogenase (Acylating)	0.060
Methylmalonate-semialdehyde dehydrogenase [acylating]	0.046