M9F60

Prompt

1.2.1.88

Oxidoreductases. Acting on the aldehyde or oxo group of donors. With NAD(+) or NADP(+) as acceptor. L-glutamate gamma-semialdehyde dehydrogenase.

AI Generated Sequence

420 AAs

MTDLTDLLTDLGRRARDAARVLARASTAQKNRALLAMADAIEANADAILAANAKDLEAGRANGLPEAMIDRLTLTEKRIDAMAEGLRDVAALPDPVGEVTAAWTRPNGLHIRRVRTPLGVIGVIYESRPNVTADAAGLCLKSGNAVILRGGSEAFHSNAAIAACVREGLEAAGLPADAVQLVPTTDRAAVGHLITARGLVDVIVPRGGKSLVERVQREARVPTFAHLEGNCHVYVDADADLDMAKRIALNAKTQRTGVCGAAETLLVHRAVADTHLPALLEALRDAGVELRGCEATRAILPGMVPATEEDWGTEYLDMILAVKVVDGVDAAIAHIRRYSSGHTDAIVTEDEAAARRFVNEVDSASVMVNASTQFADGGEFGFGAEIGISTGKLHARGPVGVEQLTSFKYLVLGDGQVRTA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	96.8
NLMSIM	85.0
AACOMP	89.6
Seqdif (SeqID)	30.6 (WP_262523489.1)
Structdif (F-Target)	2.2 (1o20 A)

ProtNLM

Name	Score
GSA dehydrogenase	0.184
GPR	0.175
Gamma-glutamyl phosphate reductase	0.163
Glutamate-5-semialdehyde dehydrogenase	0.161
Glutamyl-gamma-semialdehyde dehydrogenase	0.157
1.2.1.41	0.156