M99PT

Prompt

2.7.11.21

Transferases. Transferring phosphorus-containing groups. Protein-serine/threonine kinases. polo kinase.

AI Generated Sequence

500 AAs
MSFLKRQELRHLRQQEEKQAQQYKHVKRDLNPEEFWKIIGELGDGAFGKVYKAQNKETGVLAAAKVIETKESEEELDHMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCPGGAVDAVMLELERPLTEPQIKAVCKQMLEGLNYLHSNKMIHRDLKAGNILLTLDGDVKLADFGVSAKNTRTIQRRDTFIGTPYWMAPEVVMCETMKDGPYDYKADIWSLGITLIEMAQIEPPHHEMNPMRVLLKIKQSEPPTLLQPSKWSSEFNDFLKKCLEKNPDVRPTASQLLQHPFVTSINNNKPLRELLAEAKVEVMEEVEDGDEDEEEETETLQLPPAKKRASSDLSIASEEEDKLSQNACILPEVSEKTPKDTEEEKFKRTVKELKDKPPEAETDEHTLVTDNFLKNKEQQTIEEAVRRPLFKKNETREDIQERKLPDMVEKPSTHEKVTNDTIGLMDENTYKKLSKEQEKERRRRIMNKTKEKLTDNRKPILESEKELF

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT75.7
NLMSIM75.0
AACOMP88.6
Seqdif (SeqID)22.8 (AAH47885.1)
Structdif (F-Target)3.3 (4usd A)

ProtNLM

NameScore
2.7.11.10.618
Non-specific serine/threonine protein kinase0.262
SLK kinase0.032
Serine/threonine-protein kinase 100.021
STK10 kinase0.014
STE20-like kinase0.008
Designed by MP, using an AMD MI250 GPU