M97LJ

Prompt

1.13.11.34

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. arachidonate 5-lipoxygenase.

AI Generated Sequence

252 AAs
MPSYTVTVATGSQWFAGTSDYIYLSLVGTAGCSEKHLLDKPFYRDFERGAVDSYDVTCVEDLGELQLVKIEKRKYWLNDDWYCKYITVKTPTGDYLEFPCYRWITDEDEIVLRDGRAKLPRDDKTLILKQHRRKELENRQKQYRWEEWQPGFPLSIDASIHKDLPRDIQFDSEKGIDFTLNYSKAIENINFRGFMHMFQSWSDFADFEKIFVRISTSIAERVMEHWQEDMFFGYQYLNGCNPVLIRRCTKLP

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT73.8
NLMSIM95.0
AACOMP91.2
Seqdif (SeqID)17.0 (XP_044617581.1)
Structdif (F-Target)22.4 (4nre A)

ProtNLM

NameScore
Arachidonate 5-lipoxygenase0.461
LOX5 lipoxygenase0.370
Arachidonate 5-lipoxygenase-like0.045
Arachidonate 5-lipoxygenase a0.026
Arachidonate 5-lipoxygenase b, tandem duplicate 20.019
Arachidonate 5-lipoxygenase-like protein0.011
Designed by MP, using an AMD MI250 GPU