M960B

Prompt

1.14.19.58

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. tryptophan 5-halogenase.

AI Generated Sequence

280 AAs
MKKINKVIIVGGGTAGWMAAAYLSKVLGKDTDITVVESPEIGTVGVGEATIPPIRKFNQMLGIDEKEWMRHTNATFKLGIEFRNWGRLGDSYIHNFGTLGHDLPGMGFHQFWLRAKENGLEAPLSDYSCSQLAAQNGKFATPSPNNPLLSIDYAYHFDGGLYAKFLRSYAERNGVTRTEGKIAEVEQDPEDGFISSLVLENGRIEGDLFVDCSGFRGLLIEQTLKTGHYDTWSHLLPTDRALAVPCETNPPIKPYTRAIAHEAGWQWRIPLQHRTGNGHV

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT90.8
NLMSIM80.0
AACOMP94.1
Seqdif (SeqID)36.9 (MCE2943198.1)
Structdif (F-Target)4.6 (6y1w B)

ProtNLM

NameScore
Tryptophan halogenase0.762
Tryptophan 7-halogenase0.156
1.14.19.90.015
Flavin-dependent tryptophan halogenase RebH0.012
Tryptophan 5-halogenase0.005
Tryptophan halogenase,0.002
Designed by MP, using an AMD MI250 GPU
EC Repo - M960B | 310.ai