M913L

Prompt

1.4.1.24

Oxidoreductases. Acting on the CH-NH2 group of donors. With NAD(+) or NADP(+) as acceptor. 3-dehydroquinate synthase II.

AI Generated Sequence

365 AAs

MKRSVWLKADSGVGDWEEQKRRITGGLEAGVDAVLVDPEDVERVRELGNITVAGFADGADKVVVGDGEDLPDFSGADLSTLRKQGKEVRGYFVRIKDSKYEEFAVQAGKAADYTIVVGKDWKIIPLENLIAELQGETTKIIAGVQTAAEARTAFETLEHGADGVLLDSDDPQEIKRVAEAAERSELELLPATVTKVEQLGMGDRVCIDTCGSFMQGEGMLVGSMSRGMFLVHSETVESPYVASRPFRVNAGAVHAYIRTPDGKTKYLSELSSGDEVLVVDSNGRTREAIVGRVKIEKRPMLLIEAEVEGERIRTLLQNAETIKLVGPDGKTPSVAELKPGDKVLVHLEDTARHFGMEIEETIVEK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	86.1
NLMSIM	70.0
AACOMP	91.8
Seqdif (SeqID)	37.2 (WP_256288060.1)
Structdif (F-Target)	28.7 (2h6r A)

ProtNLM

Name	Score
DHQ synthase	0.424
3-dehydroquinate synthase II	0.195
1.4.1.24	0.179
3-dehydroquinate synthase	0.156
4.2.3.4	0.013
3-dehydroquinate synthase homolog	0.003