M8WM6

Prompt

1.2.1.27

Oxidoreductases. Acting on the aldehyde or oxo group of donors. With NAD(+) or NADP(+) as acceptor. methylmalonate-semialdehyde dehydrogenase (CoA acylating).

AI Generated Sequence

499 AAs

MTTTTPHFIDGKIVEGSSDRFADVFNPMTGEVQAKVPLGSKEEVDAAVANAKAAQPAWAATNPQRRARVMMKFVELVNENMDELAELLSREHGKTLPDAKGDVQRGIEVVEFACGIPHLMKGEFTENAGPGIDVYSMRQPLGVVAGITPFNFPAMIPLWKAPVAIACGNAFILKPSERDPSVPMRLAELMKEAGLPKGVLNVVNGDKEAVDAILTDPDIKAVSFVGSTDIAQYIYGTGTANGKRAQCFGGAKNHMIIMPDADLDQAVDALMGAGYGSAGERCMAISVAVPVGDETADRLKAKLIPRIESLKVGPSTDPKADYGPVVTAAHKEKVEGYIDSGVKEGAELVVDGRDFKLQGYEDGYFVGGTLFDHVTPDMKIYKEEIFGPVLSIVRAKTYEEALQLPSNHEYGNGTCIFTRDGDAARDFASRINVGMVGINVPIPVPVAYHTFGGWKRSGFGDLNQHGPESVRFYTKTKTITSRWPSGIKEGAEFSIPTMK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	92.5
NLMSIM	85.0
AACOMP	93.0
Seqdif (SeqID)	19.2 (WP_055459566.1)
Structdif (F-Target)	1.7 (4iym C)

ProtNLM

Name	Score
CoA-acylating methylmalonate-semialdehyde dehydrogenase	0.266
Methylmalonate-semialdehyde dehydrogenase	0.197
Methylmalonate-semialdehyde dehydrogenase (CoA acylating)	0.189
1.2.1.27	0.135
Methylmalonate-semialdehyde dehydrogenase (Acylating)	0.061
Methylmalonate-semialdehyde dehydrogenase [acylating]	0.046