M8G0C

Prompt

1.3.1.88

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)].

AI Generated Sequence

361 AAs

MKIVLAPMEGLVDDIMRDVLTRVGGFDLCVTEFVRVTDRLLPPRVFHRLCPELLNGGRTPAGTPVRVQLLGQDPACMAENAARAAELGAPGIDLNFGCPAKTVNRHRGGAVLLKEPELLHAIVAAVRAAVPAHIPVSAKMRLGFEDPSLALDCAQAIEAGGAAHLVVHARTKVEGYKPPAHWEWIARIREAVSVPVIANGEIWTVEDARRCREVSGCEDIMLGRGLVARPDLARQIAAYRAGEEPAPMPWAELLPLLRDFWTLARARLEPRYAPARLKQWLAMLKRSYPEAEALFAAVRRTDDPARVAALLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	93.2
NLMSIM	85.0
AACOMP	80.3
Seqdif (SeqID)	25.6 (WP_247847137.1)
Structdif (F-Target)	3.1 (4yco B)

ProtNLM

Name	Score
1.3.1.-	0.248
TRNA-dihydrouridine synthase C	0.236
TRNA-dihydrouridine(16) synthase	0.193
U16-specific Dus	0.187
U16-specific dihydrouridine synthase	0.122
Dus domain-containing protein	0.001