M7TWP

Prompt

1.1.1.189

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. prostaglandin-E2 9-reductase.

AI Generated Sequence

577 AAs

MSVERVVVRLGGRPNGVPVTDNFRLETEEVPEVNEGQVVLRNLYLSLDPYMRGRMDDVGSYVSPWEVGEVMAGGTVGRVIESKHPGFAPGDVVLGNFAWQEYAVIDGGELVKIDPHLGLPLSYLGGVMGMGLTAYAGILEVGRPKAGQTVVVSGAAGAVGSVAGQIGRLKGAGRVVGIAGGDEKCAVLKEELGFDAAINYKEPNVAEALRKAAPEGYDVYFDNVGGDIADAVISQMNRFGRIVLCGQISQYNNREPYPEPPNLREAIQKERTMREGFIVSRYNDRYEGALLDLSAWVREGKLKIRETVVEGLENMGQAFLGLLKGGNTGKQIVKVAEGGQVVVESKHNPEFAAGDVVLSNTAPWQTYAILDGGALEKVDPKLGQPLSLYLGTVGMTGLTAYAGIREVCGAPKGGQTVVVSGAAGAVGSLAGQIAKLHGAERVVGIAGTDEKCAVLKEELGFDAAINYKEVPDVAAQLREAAPEGVDVYFDNVGGDIADAVVAQMNRFGAHIALCGQISQYNNREVPYGEVLDLSGWVREGKIKYRETVVEGLENMAQAFLGLLKGGNTGKQVVKVAE

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	85.0
NLMSIM	85.0
AACOMP	89.8
Seqdif (SeqID)	59.8 (KAG7302504.1)
Structdif (F-Target)	5.3 (2w98 A)

ProtNLM

Name	Score
NADP-dependent oxidoreductase	0.685
PKS_ER domain-containing protein	0.076
Zinc-binding dehydrogenase	0.038
NADP-dependent oxidoreductase YfmJ	0.032
1.-.-.-	0.020
Oxidoreductase YncB	0.016