M7OJO

Prompt

1.14.13.33

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of one atom of oxygen. 4-hydroxybenzoate 3-monooxygenase [NAD(P)H].

AI Generated Sequence

214 AAs

MRTQVAIIGAGPSGLLLGQLLTKAGIDNVILERKSRDYVLGRIRAGVLEEGTVDLLEQAGVSSRMHAEGVPHDGIEFAFDGKHYRIDLKELTGNRVTVYTGQTEITRDLYEERKAAGVPTVYEAKDVTLHFDSTDKPYVTYVREGVTHRILCDFIAGCDGFHGISRSPISKQALETFEKYVPFGWLGILSDVPDVSHELIYANSFGRFALCMSR

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT	88.7
NLMSIM	90.0
AACOMP	93.8
Seqdif (SeqID)	31.3 (WP_302077137.1)
Structdif (F-Target)	5.7 (1pbe A)

ProtNLM

Name	Score
1.14.13.2	0.608
4-hydroxybenzoate 3-monooxygenase	0.289
P-hydroxybenzoate hydroxylase	0.034
4-hydroxybenzoate hydroxylase	0.020
FAD_binding_3 domain-containing protein	0.007
Kynurenine 3-monooxygenase	0.003