M6RH3

Prompt

1.1.1.330

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. very-long-chain 3-oxoacyl-CoA reductase.

AI Generated Sequence

371 AAs

MKFLGLLGLLGLLLAARLLPLLGLLLDLFLLPGKDLRSYGKGKKWVAVTDASDKLGEEYALQTAKAGFNVLLVSRTQAKLETLAEEILAKYGVTQTKVLNLDFASKNDADYEALKALVAQLDVGILINNVGQSHSIPVPFLATPKAEMQNIITINNCGTLLITQLVAPIMQQTKRGLILTMGAFGGLLPTPYLATYASSKAFLQQWSTALASELAPHGIDVELVQSYLVTSAMSKIRRSALLIPNPRQFVKATLKSIGRNGAPQNYAYTMPYWAHGALMQWIETTLGPTNALLHLLNLSMSHSIRKAFGLKAAERKAKQQKAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	92.4
NLMSIM	70.0
AACOMP	83.8
Seqdif (SeqID)	40.3 (KAI9651295.1)
Structdif (F-Target)	10.9 (5fyd A)

ProtNLM

Name	Score
KAR	0.324
Microsomal beta-keto-reductase	0.182
Very-long-chain 3-oxoacyl-CoA reductase	0.157
1.1.1.330	0.130
3-ketoreductase	0.116
3-ketoacyl-CoA reductase	0.058