M6L10

Prompt

1.1.1.88

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. hydroxymethylglutaryl-CoA reductase.

AI Generated Sequence

475 AAs

MTTSRIPGFYRLSPAERLAHVAAQAGLTDEELALLANPGALPLTVADRMIENVIGTFELPLGLAPNFLINGRDYLVPMAVEEPSVVAAASYMAKLARERGGFTATSSEPLMRAQIQIVGVADPHAARLAILAAKDEILALANARDPTLVKRGGGARDLEVHVFPTPSGPMVVVHLIVDTRDAMGANTVNTMAEAVAPLIEEITGGTVRLRILSNLADLRLARARARIAAEDLATREYGGEEVIDGILDAYAFAAADPYRAATHNKGIMNGIDPVVIATGNDWRAVEAGAHAYAARSGRYTSLTEWEKDADGNLVGTIEMPMAVGLVGGATKTHPLARLSIEILGVKSARELAEVIVAVGLAQNFGALRALATEGIQRGHMALHARNIAVAAGARGDEIDLVAARMVADGAIRTDRAKEVLAELRAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	86.0
NLMSIM	95.0
AACOMP	85.6
Seqdif (SeqID)	24.6 (WP_095743060.1)
Structdif (F-Target)	6.5 (5wpk B)

ProtNLM

Name	Score
HMG-CoA reductase	0.397
1.1.1.88	0.292
3-hydroxy-3-methylglutaryl coenzyme A reductase	0.266
Hydroxymethylglutaryl-CoA reductase, degradative	0.030
1.1.1.34	0.004
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase	0.001