M69J7

Prompt

2.7.11.10

Transferases. Transferring phosphorus-containing groups. Protein-serine/threonine kinases. IkappaB kinase.

AI Generated Sequence

500 AAs
MNRPLQLKQQTCGSWEMKERLGTGGFGNVYLWQHQETGEKIAIKQCRLELSSKNKERWCHEIQIMKKLNHPNVVKACDVPEEMALNDVPLLAMEYCSGGDLRKLLNKPENCCGLKEGQILTLLSDIGSAIRYLHENKIIHRDLKPENIVLQDVEGKIIHKIIDLGYAKDLDQGSLCTSFVGTLQYLAPELLENQKYTVTVDYWSFGTLVFECIAGFRPFLPNLQPFTWHEKVKQKGPKDIFVYEELNGTVKFSTHLPQPNNLCSLIAEPMEKWLQLMLNWDPRQRGGTVDYTPKPNCFKALDHILNLKIVHILNMVSGKITSFPVTPDESLHSLQARIERDTGIDTGNQELLLEAGIALDPRKPATQCVIDGVKGVDYDMVYLFDNSKMTYEGPFAPRSLPDSVNYIVQDSKKQLPIPFLRKVWGEAVHYIIGLKEDYCRLFQGQRAAMLNLLRYNANLTKMKNNMVSMSQQLKAKLDFFKTSIQIDLEKYSDQMTYGIA

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT85.9
NLMSIM90.0
AACOMP92.2
Seqdif (SeqID)21.1 (XP_015312021.1)
Structdif (F-Target)8.2 (5ebz L)

ProtNLM

NameScore
2.7.11.100.381
I-kappa-B kinase0.330
Nuclear factor NF-kappa-B inhibitor kinase alpha0.124
Inhibitor of nuclear factor kappa-B kinase subunit alpha0.103
IkBKA0.013
IKKA kinase0.004
Designed by MP, using an AMD MI250 GPU