M5UM8

Prompt

1.3.1.15

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. dihydroorotate dehydrogenase (NADP(+)).

AI Generated Sequence

393 AAs
MLYPLLRKLLFQLDPERAHELTIGALKRLYGLPLLGLYRQPLPLRPVTVMGLNFPNPVGLAAGLDKNGEAIDALHAMGFGFVEVGTVTPRPQPGNDKPRLFRLVPAEAIINRMGFNNHGVDALVANLRAARFGGILGVNIGKNKDTPNEQGADDYLICMDRVYPLAGYVAVNISSPNTPGLRQLQYADALDELLAALRERQLELAARHGKRVPLALKIAPDLTDGEIEQAAAALLATRIDGVIATNTTLDRAGVAGLPHAGEAGGLSGAPLQARSTLVLRRLAARLGGALPIIGVGGIDSGAAARAKLAAGADLVQVYSGFIYRGPGLIGECVAALAARRAAAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT90.9
NLMSIM70.0
AACOMP82.3
Seqdif (SeqID)28.2 (WP_143237545.1)
Structdif (F-Target)2.2 (7t6h B)

ProtNLM

NameScore
DHOdehase0.212
DHODase0.181
1.3.5.20.176
Dihydroorotate oxidase0.160
DHOD0.144
Dihydroorotate dehydrogenase (quinone)0.118
Designed by MP, using an AMD MI250 GPU