M5TVR

Prompt

1.1.1.21

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. aldose reductase.

AI Generated Sequence

314 AAs

MTTTTTFTLNNGAKMPAIGLGTWQSVPGETRDAVTHAIKVGYRHIDTAAVYGNEKEVGEGIRKGIADGVKREDLFVTSKLWNTFHREDVEPALDKSLKDLQLDYLDLYLIHWPVAFKVGDHPFPKDDGKMIPMDDVNFHDTWKAMEKLVDEGKVKAIGVSNFSVKQLEDLLKYAKIVPAVNQIECHPYLPQEKLLEYCHSKGIHVTAYSPLGSQLLGPKVGNGVPVLEDPTIKEIAEKHKKTPAQVILRWAIQRGVAVIPKSVTKSRIEENFQVIDFDLTEEDMKEISSLNKNIRFNDPVFDSGHEPFPIDEAY

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	90.8
NLMSIM	70.0
AACOMP	92.2
Seqdif (SeqID)	45.5 (XP_054142016.1)
Structdif (F-Target)	4.9 (2pdl A)

ProtNLM

Name	Score
Aldo_ket_red domain-containing protein	0.439
Aldo/keto reductase	0.088
Aldose reductase	0.037
Aldehyde reductase	0.030
Alcohol dehydrogenase (NADP+)	0.026
Aldo-keto reductase	0.026