M5LRD

Prompt

1.1.1.102

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. 3-dehydrosphinganine reductase.

AI Generated Sequence

356 AAs

MSFDLKGKTVLITGGSQGIGKAIALELAKRGAHVTIVARNEAKLEEAVAEIEAAGHDRFVAYAADVSDYAAVEAAIAAAEADFGRVDILVNCAGFARPGKFEDMTVEDFRRQMDVNYLGSVYTAHAAVPAMKARGRGRIVFSSSVAGLFGIFGYAAYSASKYALRGLAEALRQEIAPYNINVTVAYPGTTDTPGFAEENKTKPALTRLIESEAPVCTPEEVAAKIIKGLEAGNFDITTNDVGHWLMRSLTAGMSPRNTFGDGFVQWVTLGLYRITAVFPNYFDRIVRRCMEAKQKGLDKPAAEGGNGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	84.7
NLMSIM	70.0
AACOMP	83.6
Seqdif (SeqID)	46.1 (XP_058133841.1)
Structdif (F-Target)	8.1 (2bel A)

ProtNLM

Name	Score
SDR family oxidoreductase	0.308
Short-chain dehydrogenase	0.219
SDR family NAD(P)-dependent oxidoreductase	0.126
3-dehydrosphinganine reductase	0.100
Short-chain dehydrogenase/reductase SDR	0.045
3-ketodihydrosphingosine reductase	0.030